Question

Prions are infectious particles that can cause normal proteins to assume a misfolded shape. when the proteins assume an abnormal three- dimensional shape, they:_________

Answer 1

Lose their function.

Prions are infectious particles that can cause normal proteins to assume a misfolded shape. when the proteins assume an abnormal three- dimensional shape, they lose their function.

What causes misfolding in prions?

• Transmissible spongiform encephalopathies are linked to the human prion protein's (PrP) abnormal folding and aggregation (TSEs).
• The transformation of PrP from its cellular form into its pathological scrapie conformation produces intermediate conformations, which are a significant factor in the misfolding process.

Protein shapes are they altered by prions?

• Normal PrPC proteins can be transformed into the infectious isoform by the infectious isoform of PrP, also known as PrPSc or simply the prion, by changing their conformation, or shape, which then changes how the proteins attach to one another.

How can misfolded proteins called prions spread disease?

• The self-replicating isoform of the endogenous prion protein, PRP(c), which binds to the cellular PRP and transforms it into the infectious self-replicating form, is thought to be the mechanism that creates prions.

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