Question

Rank the following one-base point mutations with respect to their likelihood of affecting the structure of the corresponding polypeptide (from most likely to least likely).
1. insertion mutation deep within an intron 2. substitution mutation at the third position of a codon in an exon 3. substitution mutation at the second position of a codon in an exon
4. deletion mutation within the first exon of the gene (A) 1,2,3,4 (B) 4,3,2,1 (C) 2,1,4,3 (D) 3,1,4,2

Answer 1

The rank from most likely to least likely of the one-base point mutations  will be: (B) 4, 3, 2, 1

4. deletion mutation within the first exon of the gene.

3. substitution mutation at the second position of a codon in an exon.

2. substitution mutation at the third position of a codon in an exon.

1. insertion mutation deep within an intron.

Insertion mutation can affect the structure but only when present in the axon. Deletion mutation can change the whole reading frame pf the m-nucleotide sequence.

Substitutions can at maximum change one amino acid in the reading frame as one amino acid will be replaced by another. And if the substitutions is at the third place of the codon triplet, chances are that the amino might not even change as one amino acid are coded by more than pone codons.

To know more about substitutions, here

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