Question

The nurse wants to discuss the biotransformation reaction to a student. what is the best explanation by the nurse?

Answer 1

Biotransformation converts drugs from one form to another which can result in increased or decreased activity.

What do you mean by the term Biotransformation?

Biotransformation is the process by which chemicals that enter the body are transformed from hydrophobic to hydrophilic molecules to aid removal from the body. Typically, this technique produces compounds that have little to no toxicological consequences. Through a process known as bioactivation, hazardous metabolites can occasionally result from biotransformations. Phase I and Phase II biotransformations are the chemical processes that convert a lipophilic toxin into a chemical form. Based on the catalyzed reactions, the two groups are separated. Phase I reactions use oxidation, hydrolysis, or related processes to convert hydrophobic compounds into more polar products.

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