The overexpression results in increased micro vessel density and lesion size in mice with induced endometriosis.
Endometriosis is a benign gynecological disorder.
it's far characterized through the ectopic presence of endometrial glands and stroma out of doors of the uterine hollow space and is carefully related to dysmenorrhea, pelvic pain, and subfertility.
In endometriosis, the involvement of vascular endothelial mobile growth issue (VEGF) and different angiogenic mediators has long been recognized endometriotic angiogenesis entails numerous pathways and the blockade of simply one single pathway won't effectively suppress Endometriosis
Slit is a secretory glycoprotein which include 3 members, Slit1, Slit2, and Slit3, and become at first found to be secreted repellents in axon steerage and neuronal migration It has been shown to be an endogenously available inhibitor of leukocyte chemotaxis.
receptor for Slit is the protein Roundabout (ROBO), which currently includes 4 members (ROBO1-4)
