Question

Why does a second stimulus early in the relative refractory period have to be stronger to initiate an action potential?

Answer 1

A second stimulus, must be greater early in the relative refractory phase because the membrane is hyperpolarized and the threshold voltage is greater.

In biology, a membrane is a thin layer that forms the outside border of a live cell or an internal cell compartment. The plasma membrane serves as the exterior barrier, while the compartments contained by interior membranes are known as organelles.

Biological membranes serve three primary functions: they keep toxic substances out of the cell; they contain receptors and channels that allow specific molecules that mediate cellular and extracellular activities, such as ions, nutrients, wastes, and metabolic products, to pass between organelles and between the cell and the outside environment; and they separate vital but incompatible metabolic processes conducted within organelles.

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