Question

Which clinical manifestation, when found in newborns, may indicate the presence of cystic fibrosis?

Answer 1

Meconium ileus, in newborns, may indicate the presence of cystic fibrosis

Cystic fibrosis is a genetic disorder mainly associated with cells capable of producing mucus. These cells are found in sweat glands, digestive system and lungs belonging to respiratory system. Thus, the abnormality in mucus production, in sticky and thick nature, disrupts the normal functioning of human body. They block the ducts and tubes, which can result in life threatening condition.

The mutation responsible for cystic fibrosis occurs in the gene CFTR, which is abbreviated form of Cystic fibrosis trans membrane conductance regulator. The primary function of gene is to regulate the exchange of fluids and salts present in the cells.

Meconium ileus refers to the inability of bowel movement in the newborn. This occurs due to thick and sticky mucus, which is indicative of cystic fibrosis, as discussed above.

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