Question

cd103 and cd103 bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to cd4 and cd8 t cells.

Answer 1

The correct answer is because these cells are largely absent in CCR7(-/-) mice derived from the lung and that CCR7 expression is required for their migration from the lung to the draining lymph node.

Cross-presentation occurs when dendritic cells (DC) capture, process, and present exogenous Ag to CD8(+) T lymphocytes via MHC class I. We show that CD103(+) (CD11c(high)CD11b(low)) and CD103(-) (CD11c(int)CD11b(high)) DC in the lung-draining bronchial lymph node (brLN) have evolved to have opposing functions in presenting innocuous inhaled Ag. Thus, under tolerogenic conditions, CD103(-) DC present innocuous Ag to CD4(+) T cells, whereas CD103(+) DC, which do not express CD8alpha, present Ag exclusively to CD8(+) T cells. Ag-carrying CD103(+) DC are largely absent in the brLN of CCR7-deficient mice but not in plt/plt mice, despite the presence of CD103(+) DC in the lung of CCR7-deficient mice.

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