Question

Induction of peripheral tolerance in T cells: Please choose the correct answer from the following choices, and then select the submit answer button. can be caused by interaction with MHC/peptide in the absence of costimulation. can be caused by costimulation in the absence of MHC/peptide. usually leads to apoptosis. The first and third answers describe this form of induction. The second and third answers describe this form of induction.

Answer 1

Answer:

can be caused by interaction with MHC/peptide in the absence of costimulation

Explanation:

T cells represent a class of white blood cells (lymphocytes) that have a major role in the adaptive immunity of the organism against specific pathogens. Peripheral tolerance is a type of immunological tolerance aimed at ensuring B and T cells that escaped from the central tolerance mechanism do not produce autoimmune diseases. Some populations of lymph node cells can induce peripheral tolerance in T helper cells (Th cells, CD4+ cells) by the presentation of peptide-MHCII (major histocompatibility complex type II) complexes acquired from dendritic cells. These dendritic cells are antigen-presenting cells that play a key role in adaptive immunity, which are well-known to induce CD4 and CD8 T cell tolerance in response to antigens (peptides/proteins).