Induction of peripheral tolerance in T cells: Please choose the correct answer from the following choices, and then select the s
ubmit answer button. can be caused by interaction with MHC/peptide in the absence of costimulation. can be caused by costimulation in the absence of MHC/peptide. usually leads to apoptosis. The first and third answers describe this form of induction. The second and third answers describe this form of induction.
can be caused by interaction with MHC/peptide in the absence of costimulation
Explanation:
T cells represent a class of white blood cells (lymphocytes) that have a major role in the adaptive immunity of the organism against specific pathogens. Peripheral tolerance is a type of immunological tolerance aimed at ensuring B and T cells that escaped from the central tolerance mechanism do not produce autoimmune diseases. Some populations of lymph node cells can induce peripheral tolerance in T helper cells (Th cells, CD4+ cells) by the presentation of peptide-MHCII (major histocompatibility complex type II) complexes acquired from dendritic cells. These dendritic cells are antigen-presenting cells that play a key role in adaptive immunity, which are well-known to induce CD4 and CD8 T cell tolerance in response to antigens (peptides/proteins).
