1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
Alex Ar [27]
1 year ago
11

as-120 overcomes resistance to atp-competitive fgfr inhibitors in patients with fgfr2 fusion–positive intrahepatic cholangiocarc

inom
Biology
1 answer:
lilavasa [31]1 year ago
3 0

TAS-120 helps the patients in becoming resistant to BGJ398 and FGFR2 mutations.

Anti-tumor activity has been observed in the patient with intrahepatic cholangiocarcinoma (ICC) that activates ATP-competitive fibroblast growth factor receptor gene fusions. This results in resistance and results in the development of mutation of FGFR2 kinase.

It was further reported in 4 patients with FGFR2 that they developed Debio 1347. It was due to the activation of TAS-120 that fight the FGFR2.TAS-120 is the inhibitor of FGFR and it is irreversible. In patients with FGFR2, an increase in the duration of FGFR inhibition, FGFR inhibitors can be sequenced in a planned manner along with the biopsy.

TAS-120 helps the patients in becoming resistant to BGJ398 and FGFR2 mutations.

To know more about mutation, refer to the below link:

brainly.com/question/9598940

#SPJ4

You might be interested in
How do non-native species affect the populations within the ecosystem where they are introduced?
Veronika [31]

Answer:

Invasive species cause harm to wildlife in many ways. When a new and aggressive species is introduced into an ecosystem, it may not have any natural predators or controls. ... Invasive species can also alter the abundance or diversity of species that are important habitat for native wildlife.

Explanation:

3 0
3 years ago
Read 2 more answers
Whats a vascule bundle?​
mestny [16]

Answer: A vascular bundle is a part of the transport system in vascular plants. A strand of conducting vessels in the stem or leaves of a plant, typically with phloem on the outside and xylem on the inside.

Hope this helps you!

6 0
2 years ago
Read 2 more answers
Y=x2-1. Is it linear
yanalaym [24]
No if it is squared it is a parabola. To be linear it has to be. A straight line
4 0
3 years ago
Read 2 more answers
What patterns can be observed in evolution
Elodia [21]
Genetics, adaption, colonization
5 0
3 years ago
A tall pea plant (Tt) is crossbred with a short pea plant (tt). The following Punnett square shows the separated alleles for two
neonofarm [45]
C <span>1 = Tt; 2 = Tt; 3 = tt; 4 = tt</span>
4 0
3 years ago
Read 2 more answers
Other questions:
  • PLEASE HELP!! Lily visits her family doctor because she experiences an upset stomach after drinking milk. The doctor tells her t
    14·1 answer
  • Giving BRAINLIST if you help fast!!
    10·2 answers
  • The sequence of DNA below is replicating itself.
    7·1 answer
  • Why can we sometimes hear noises in the stomach during digestion???
    14·1 answer
  • What macromolecule is composed of CHNOP? Select all that apply
    10·1 answer
  • During cellular respiration, the bonds of food molecules are broken, so energy can be released to fuel other cellular processes.
    13·2 answers
  • California’s borders which ocean?
    11·2 answers
  • What does passive transport mean
    10·1 answer
  • I need help plz!!!!!!!!why are the structures of plants ideal for photosynthesis? ​
    11·1 answer
  • What's the difference between human skin and the cell membrane !! I WILL MARK AS BRAINLIEST
    12·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!