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Alex Ar [27]
2 years ago
11

as-120 overcomes resistance to atp-competitive fgfr inhibitors in patients with fgfr2 fusion–positive intrahepatic cholangiocarc

inom
Biology
1 answer:
lilavasa [31]2 years ago
3 0

TAS-120 helps the patients in becoming resistant to BGJ398 and FGFR2 mutations.

Anti-tumor activity has been observed in the patient with intrahepatic cholangiocarcinoma (ICC) that activates ATP-competitive fibroblast growth factor receptor gene fusions. This results in resistance and results in the development of mutation of FGFR2 kinase.

It was further reported in 4 patients with FGFR2 that they developed Debio 1347. It was due to the activation of TAS-120 that fight the FGFR2.TAS-120 is the inhibitor of FGFR and it is irreversible. In patients with FGFR2, an increase in the duration of FGFR inhibition, FGFR inhibitors can be sequenced in a planned manner along with the biopsy.

TAS-120 helps the patients in becoming resistant to BGJ398 and FGFR2 mutations.

To know more about mutation, refer to the below link:

brainly.com/question/9598940

#SPJ4

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Why would your muscle cells switch to anaerobic respiration if it doesn't produce as much ATP?
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Answer:

Lack of oxygen

Explanation:

There are two mechanisms for energy production (glucose breakdown), aerobic and anaerobic. When adequate amounts of oxygen are present, aerobic mechanism is used. However, when there is insufficient oxygen, such as during exercise, the anaerobic mechanism is used.

6 0
3 years ago
A researcher is using a modified version of FRAP. She has devised a technique that allows her to label all the peripheral membra
asambeis [7]

Answer:

The correct answer is option B.

Explanation:

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In the given question, as the fluorescence has recovered back to the bleached region. The scientist can come to the conclusion that the membrane of the cell and the peripheral membrane proteins do not always belong together.  

3 0
4 years ago
State one effect the reintroduction of the
Natali [406]

We can confirm that the reintroduction of the wolf to the ecosystem would most likely cause a decline in the population of coyotes.

<h3>Why would this cause a decline in the population of coyotes?</h3>

The wolf, in most ecosystems, is considered to be the top predator. This means that it will also hunt and consume the coyotes. This alone would cause a decline in the coyote population as they now have an additional predator hunting them. Also, the wolves would be competing with the coyotes for food sources, furthering the impact on the coyote population.

Therefore, we can confirm that the reintroduction of the wolf to the ecosystem would most likely cause a decline in the population of coyotes.

To learn more about ecosystems visit:

brainly.com/question/1673533?referrer=searchResults

#SPJ1

6 0
2 years ago
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Answer:

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