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Alex Ar [27]
1 year ago
11

as-120 overcomes resistance to atp-competitive fgfr inhibitors in patients with fgfr2 fusion–positive intrahepatic cholangiocarc

inom
Biology
1 answer:
lilavasa [31]1 year ago
3 0

TAS-120 helps the patients in becoming resistant to BGJ398 and FGFR2 mutations.

Anti-tumor activity has been observed in the patient with intrahepatic cholangiocarcinoma (ICC) that activates ATP-competitive fibroblast growth factor receptor gene fusions. This results in resistance and results in the development of mutation of FGFR2 kinase.

It was further reported in 4 patients with FGFR2 that they developed Debio 1347. It was due to the activation of TAS-120 that fight the FGFR2.TAS-120 is the inhibitor of FGFR and it is irreversible. In patients with FGFR2, an increase in the duration of FGFR inhibition, FGFR inhibitors can be sequenced in a planned manner along with the biopsy.

TAS-120 helps the patients in becoming resistant to BGJ398 and FGFR2 mutations.

To know more about mutation, refer to the below link:

brainly.com/question/9598940

#SPJ4

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A plant's life cycle alternates between<br> and<br> generations.
Arlecino [84]

Answer:

The correct answer is - haploid gametophyte and diploid sporophyte.

Explanation:

All plant life cycle shows alternation of generation. A plant's cycle alternates between haploid and diploid generation. The haploid generation is called gametophytic generation whereas the sporophytic generation.

The multicellular haloid structure of plants called sporophytic generation and these undergo meiotic or reduction division to produce the spores. These spores give rise to a haploid multicellular structure called gametophytic generation.

5 0
3 years ago
Nuclear proteins having a molecular mass more than approximately 40 KDa must be actively imported through nuclear pore complexes
patriot [66]

Answer:

Nuclear Localization Signal (NLS).

1. Importin

2. Nucleoporin

3. RanGTP

Explanation: The specific amino acid sequence motif that allows the selective transport of proteins having a molecular mass more than approximately 40 KDa into the nucleus is called Nuclear Localization Signal (NLS).

These proteins enter the nucleus through the Nuclear Pore Complex (NPC). The transit of the protein from the cytoplasm to the nucleus requires binding to a <u>receptor</u> called Karyopherin or Importin β, this receptor binds to the protein by <em>direct recognition of the NLS</em> sequence or through <em>an adapter </em>protein, Importin α (depending on the NLS sequence).

The passage of the complex through the NPC needs, in turn, the <em>binding of the </em><em>Importin </em><em>to the </em><em>Nucleoporins</em>, <u>proteins that form the nuclear pore</u>.

Once the complex passes through the pore, the <em>receptor-bound protein is released</em> <em>by the interaction</em> of Importin with RanGTP, an enzyme with guanosine triphosphate (GTP) hydrolytic activity.

5 0
2 years ago
Choose one plant or animal. Be as
12345 [234]

Answer:

Kangaroo

Explanation:

Kangaroos have adapted to their environment by being able to go longer without water due to their climate

the kangaroos front arms are shorter than their hind legs to make up less weight for longer, higher jumps/hops

Kangaroos tail is long and strong which is used for balance when hoping and standing

i think this is what you mean...hope it helps

3 0
3 years ago
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almond37 [142]

Answer:

C

Explanation:

The correct sequence of these Genes on the X chromosome is sc v s (v in the middle)

7 0
3 years ago
How is a brain injury classified?
Murljashka [212]
I think it's B an injury to the central nervous system.
8 0
2 years ago
Read 2 more answers
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