Question

Cytokines trigger endothelial cells to express specific receptors called _____ , which bind to _____ on the surface of neutrophils.

Answer 1

Cytokines trigger endothelial cells to express specific receptors called selectins, which bind to carbohydrates on the surface of neutrophils.

Cytokines are the proteinaceous structures predominant in cell signaling. They also regulate the growth of immune cells and blood cells. They can also occur in the form of glycoproteins. The example of cytokines are interleukins, interferons, chemokines and Tumor Necrosis Factor (TNF).

Selectins are the transmembrane proteins that span the lipid bilayer only once. They belong to the family Cell Adhesion Molecules. They perform role in processes like  inflammation, lymphocyte homing, immunological responses, etc. They are localized on the membranes of endothelial cells, leukocytes and platelets.

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