Answer:
1. The difference between the normal hemoglobin protein DNA sequence and the sickle cell hemoglobin DNA sequence is a base to base shift, in this case adenine (GAG) to thymine (GTG).
2. The difference affects the amino acid sequence of the protein by replacing glutamic acid (Glu) with valine (Val).
Explanation:
In sickle cell anemia, a change in the DNA nucleotide sequence is observed, where adenine is substituted by thymine, whose expression is the change in the amino acid sequence of globine β, incorporating valine instead of glutamic acid. This represents a molecular mutation - point mutation - by subtitution, which corresponds to missense mutation.
<u>Normal hemoglobin protein in a RBC</u>
DNA CTG ACT CCT GAG GAG AAG TCT
Amino acids Leu Thr Pro Glu Glu Lys Ser
<u>Sickle cell hemoglobin protein in a RBC</u>
DNA CTG ACT CCT <em>GTG</em> GAG AAG TCT
Amino acids Leu Thr Pro <em>Val</em> Glu Lys Ser
When GAG is transcribed to mRNA, the CUC codon is obtained, which codes for glutamic acid. Thymine substitution causes the DNA sequence to change to GTG, which is transcribed as CAC, the codon that encodes the amino acid valine. The <u>change from glutamic acid to valine in β-globin causes an altered hemoglobin, giving the abnormal erythrocytes observed in sickle cell disease</u>.
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Answer:
C. CH4 + 202 – CO2 + 2H20
Explanation:
CH4+O2-CO2+H20
The above equation represents combustion of methane to produce carbon-dioxide and water.
One carbon atom is present on the reactant side as well as on the product side. Four hydrogen atoms are present on the reactant side and two hydrogen atoms on product side. In order to balance this equation, we would multiply water molecule by two. Now there are four atoms of oxygen in the product side but only two on reactant side, so we will multiply oxygen molecule by two on the reactant side. Now the equation is balanced.
The balanced chemical equation is:
CH4+202-CO2+2H2O
This equation obeys the law of conservation of mass as the mass of the reactants is same as that of the products.
Answer:
7 1 2 5 9 4 11 10 3 6 12 8
Explanation:
This is the right pattern because it was easy
Answer:
Gluteus maximus
Explanation:
I think it's this I'm not 100% sure
