Loss of islet beta cells is the pathologic abnormality most likely to be present in her pancreas at the time of her collapse.
<h3>What are islet beta cells?</h3>
The islets of Langerhans, which are cellular islands dispersed throughout the endocrine pancreas in most animals, include four main kinds of cells, the -cell being one of them. The beta-cell primarily produces and secretes the hormone insulin in reaction to glucose, while it can also do so in response to other foods, hormones, and nervous system stimulation. Adult rats have a sluggish mitotic rate in their -cells. Recent research offers fresh perspectives on the -cell's functioning. An major role for insulin/IGF-1 signaling in the control of -cell activity is suggested by the existence of functioning insulin, insulin receptors, and IGF-1 signaling pathway components. Glucokinase (GK) and ATP-dependent potassium channels have also recently been found on insulin secretory granules.
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