Subcellular in vivo time-lapse imaging and optical 687 manipulation of Caenorhabditis elegans in standard multiwell plates

Biology

1 answer:

Irina-Kira [14]2 years ago

8 0

<h3>What is in vivo time lapse for screening Caenorhabditis elegans ?</h3>

Repeated immobilisation and imaging of complete animals is necessary for high-resolution in vivo time-lapse tests.
A method for screening Caenorhabditis elegans in ordinary multiwell plates at cellular resolution throughout its lifespan using recurrent immobilisation, imaging, and optical manipulation.
Our system is completely mechanical and fluid-free, and it can run for tens of thousands of cycles without experiencing any problems.
Additionally, it supports robotics, industrial high-throughput screening platforms, and chemical as well as forward and reverse genetic screening.
This technology allows for the subcellular-resolution femtosecond laser microsurgery of single neurons in vivo and the subcellular-resolution imaging of the resulting regeneration processes.

Learn more about Caenorhabditis elegans here:

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