trichodysplasia spinulosa polyomavirus small t antigen synergistically modulates s6 protein translation and dna damage response pathways to shape host cell environment is
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Trichodysplasia spinulosa is a disfiguring skin disease caused by the trichodysplasia spinulosa–associated polyomavirus (TSPyV).¹ Like other polyomaviruses, TSPyV expresses the large T and small T (sT) antigens, but how these proteins regulate trichodysplasia spinulosa pathogenesis is unknown.
What is trichodysplasia spinulosa polyomavirus?
Trichodysplasia spinulosa is a rare cutaneous condition that has been described almost exclusively in immunocompromised patients, typically organ transplant recipients, on immunosuppressive medication regimens.
It is also known by many other names, including viral-associated trichodysplasia, viral-associated trichodysplasia, pilomatrix dysplasia, and ciclosporin-induced folliculodystrophy, although the latter name is incorrect. A total of 32 cases has been documented in the medical literature as of the beginning of 2016. Despite its rarity, TS is thought to be underdiagnosed, and the rising number of patients using immunosuppressive medication regimens raises the possibility that its occurrence may increase.According to some sources, TS is a developing infectious disease.
To learn more about trichodysplasia spinulosa polyomavirus
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