Question

in general, elastase can cleave a peptide bond after a small amino acid, such as gly, ser, val, and ala. however, it may fail to do so if these amino acids are immediately followed by a proline. what enzyme property is most likely affected by the proline? group of answer choices

Answer 1

Reduced entropy, closeness, and orientation stabilization of the transition state O the enzyme

How does the proline effect work?

According to the well-known "proline effect," peptides containing Aze and Pro selectively fragment N-terminal to the Pro/Aze residue to produce yn + ions. Contrarily, peptides that include Pip and NMeA fragment specifically C-terminal to the Pip/NMeA residue to produce bn + ions.

Proline: an enzyme or not?

A universal enzyme in all living things is proline dehydrogenase (ProDH), also known as proline oxidase (POX). It catalyzes the conversion of L-proline into delta1-pyrroline-5-carboxylate, releasing electrons that can then be transported to either electron transfer systems or molecular oxygen.

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