The blood-brain barrier requires special transporters to move amino acids and vitamins into the brain.
The BBB divides membrane transport proteins into two groups: uptake transporters and efflux transporters.
Multiple uptake transporters at the BBB are in charge of moving solutes from the bloodstream into the endothelial cells, where they eventually pass through the basolateral membrane into the brain.
Passive yet saturable GLUT1 transporters that are present in both the luminal and abluminal membranes of endothelial cells mediate glucose transport across the blood-brain barrier.
Abstract. AATs are membrane-bound transport proteins that facilitate the entry and exit of amino acids from cells or cellular organelles. AATs play a variety of physiological roles in intracellular energy metabolism, anabolic and catabolic processes, acid-base balance, neurotransmission, and other areas.
