Question

of the three 'bypass' reactions that allow gluconeogenesis to produce glucose from pyruvate, two of these reactions are also points of reciprocal regulation, and one is not - which reaction is not a point of reciprocal regulation?

Answer 1

There are three bypass reactions in gluconeogenesis, out of them the one reaction which does not show reciprocal regulation is Pyruvate carboxylase and PEP carboxykinase bypass pyruvate kinase reaction.

The three bypass reactions where the energy transfer of ATP→ADP takes place are:

• Glucose-6- phosphate bypasses the hexokinase step which is a reciprocal step
• Fructose 1,6 bisphosphate bypasses the phosphofructokinase step, this step is also a reciprocal regulating step.

• Pyruvate carboxylase and PEP carboxykinase bypass pyruvate kinase step is not a reciprocally regulated step, this reaction is the last step of gluconeogenesis leading to the formation of 2 molecules of pyruvate.

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