Question

Fluoroacetate occurs naturally in some plants and is highly toxic to mammals and insects. In cells, it is converted to fluorocitrate, which binds tightly and inhibits an enzyme crucial for cellular respiration, causing citrate buildup. To what enzyme does fluorocitrate bind?.

Answer 1

Through suppression of the aconitase enzyme in the tricarboxylic acid cycle, aconitase, fluoroacetate is extremely hazardous to humans and other mammals.

'Lethal synthesis' of an isomer of fluor citrate is the cause. fluoroacetate is present in many different plant species, and ruminant animals can die from ingesting them consists of aconitase.

With the chemical formula FCH 2 CO 2 Na, sodium fluoroacetate is an organofluoride. The taste of this colorless salt, which is utilized as a metabolic toxin, is comparable to that of sodium chloride. Potassium and sodium salts are both derived from fluor acetic acid. In 1942, a report on the efficiency of sodium fluoroacetate as a rodenticide was published.

Learn more about aconitase here

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