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kolezko [41]
11 months ago
7

DELETION OF SNORD116, A PRADER-WILLI SYNDROME CANDIDATE GENE, DOES NOT AFFECT CIRCADIAN RHYTHMS IN MICE MODELS

Biology
1 answer:
Vlada [557]11 months ago
3 0

Prader-Willi syndrome (PWS) is a gentic disorder which has an impact on numerous physiological systems. PWS affected individuals (specifically babies) experience delayed growth, significant hypotonia (low muscle tone), and feeding issues. It does effect circadian rhythms in mice models.

SNORD116, often referred to as HBII-85, is a non-coding RNA (ncRNA) molecule that contributes to the alteration of other small nuclear RNAs (snRNAs). Unlike the majority of other snoRNAs, SNORD116 is not significantly complementary to ribosomal RNA and is expressed widely in the brain (but not in PWS patients).

According to the studies, SNORD116 cause sleep defect in patients with Prader-Willi syndrome. Same observation was seen in mouse models too. Paternal expression of SNORD116 is thought to be a potential gene for the sleep disruptions/circadian rhythm’s that the majority of PWS sufferers.

To learn more about circadian rhythm click here

brainly.com/question/6434404

#SPJ4

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A person who fakes symptoms for a goal is called a _________, while a person who fakes a disease for no clear goal has a _______
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A person who fakes symptoms for a goal is called a malingerer, while a person who fakes a disease for no clear goal has a factitous disorder:

Explanation:

Malingerer is someone who attempts to shirk or escape from duty/ responsibility by feigning. Malingering is the result of a person desire to gain a reward or avoid something and it is not caused by any physical factors. While Factitious disorder entails a person acting as if he or she has a physical or mental illness.

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