Answer:
mark as brainiest please
Explanation:
Agricultural Activities
mining
urbanisation
illegal longing
forest fires
Natural causes as hurricanes, fires, parasites and floods.
<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
The study of health and disease within a geographic context and from a spatial perspective is medical geography.
God bless!
INCOMPLETE DOMINANCE INHERITANCE:
<span>5. In Andalusian fowl, B is the gene for black plumage (head feathers) and B' (pronounced "B prime") is the gene for white plumage. These genes, however, show incomplete dominance. The heterozygous (BB') condition results in blue plumage. List the genotypic and phenotypic ratios expected from the following crosses: a) black x blue b) blue x blue c) blue x white</span>
<span>6. </span><span>In snapdragons, petal color is determined by a single gene locus with two alleles making the "red" allele (R) incompletely dominant to the "white" allele (r). Heterozygotes have petals, which are neither red nor white, but pink. a) If a true-breeding red flower is pollinated with pollen from a white flower: What fraction of the seeds (F1 generation) would be expected to produce red-flowered plants? What fraction of the gametes produced by the F1 plants would be expected to bear the R allele? b) If two pink flowered plants are crossed, what genotypic and phenotypic ratios are expected among the offspring (F1 generation)?</span>
