In 313 AD, the Emperor Constantine issued the Edict of Milan, which accepted Christianity: 10 years later, it had become the official religion of the Roman Empire.
I believe it's the first one!
Answer:
Spanish Netherlands was the name for the Habsburg Netherlands ruled by the Spanish branch of the Habsburgs from 1556 to 1714. They were a collection of States of the Holy Roman Empire in the Low Countries held in personal union by the Spanish Crown (also called Habsburg Spain).
In marked new opportunities for Europeans, and opened up new forms of trade. Europeans left Europe and went over to explore and start new lives in the americas.