Question

(d) Predict the effect of a mutation that prevents the expression of AURKA on a normal (noncancerous) cell.

Answer 1

Answer:

If AURKA expression is inhibited, there will be no separation of the mitotic spindle, which will compromise mitosis and will not allow the cell cycle to function properly.

Explanation:

AURKA is essential for the proper functioning of the mitotic cell division. This is because AURKA is mainly responsible for the formation of the mitotic spindle in the cells, so that there is an adequate separation of the sister chromatids, during cell division.

If AURKA is inhibited, the mitotic spindle will not be formed, which will compromise the cell cycle.