Question

Chloramphenicol binds in the active site of the large ribosomal subunit and inhibits peptidyl transferase activity in the 23s rrna. why is this inhibition restricted to bacterial translation?

Answer 1

This inhibition is restricted to bacterial translation because; the peptidyl transferase is an enzyme aminoacyltransferase as well as the primary enzymatic function of the ribosome, which forms peptide bonds between adjacent amino acids using tRNAs during the process of translation. Therefore, inhibition of this enzyme means that the process oof translation wont take place, hence proteins will not be formed and thus the bacteria will die.