The correct answer is letter C.
Explanation: The Democratic-Republican Party was the second political party created in the United States, having been founded in 1792 by Thomas Jefferson and his friend James Madison.
You can consider it to be Isolated. The doctrine was about preventing anyone from Europe from participating in political activities in the new land, and it was proclaimed that any European force that tried to control or colonize countries in the new land would be considered to be unfriendly to the US and the US would help the countries under attack.