The best and most correct answer among the choices provided by the question is the seocnd choice "constatinople was captured by the Ottomans"
On May 29, 1453, after an Ottoman army stormed Constantinople, Mehmed triumphantly entered the Hagia Sophia, which would become the city's leading mosque. Emperor Constantine XI died in battle that day, and the decline and fall<span> of the </span>Byzantine Empire<span> was complete.</span>
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When sea routes were discovered
If countries don't buy as much land from other countries, there won't be as much disagreement over who should own what land. Countries could share the land to help prevent the war. When countries form alliances, more people will get involved in the war. Other countries that don't have alliances are angry at the countries that do.
His message in Mecca was not received well. He was being persecuted and mocked. He sought refuge in The Green Dome of Medina where he sought refuge and continued to spread the word of Islam becoming powerful and spreading Islam a d the word of Allah.