<h3><u>Answer;</u></h3>
A) Lymphatic capillaries to collecting vessels -Correct
B) Lymph nodes to lymph capillaries - Incorrect
C) Collecting vessels to lymphatic trunks- Correct
D) Collecting ducts to collecting vessels- Incorrect
E) Thoracic duct to cisterna chyli - Incorrect
F) Right sub-clavian trunk to thoracic duct - Incorrect
G) Intestinal trunk to right lymphatic duct - Incorrect
H) Left lumbar trunk to thoracic duct - Correct
I) Lower extremity lymph to thoracic duct - Correct
J) Right head lymph to thoracic duct - Incorrect
Mosunetuzumab is a T-cell reliant bispecific antibody that binds to CD3 and CD20 to trigger T-cell mediated B-cell death.
However, cytokine release syndrome, which has the potential to limit dose and efficacy, can result from powerful immune stimulation with T-cell focused treatments.
We created a novel mechanistic model of immune and antitumor responses to the T-cell bispecifics (mosunetuzumab and blinatumomab), taking into account the dynamics of B- and T-lymphocytes in circulation, lymphoid tissues, and tumors, in order to better understand the mechanisms underlying safety and efficacy as well as to explore safety mitigation strategies.
Using mosunetuzumab nonclinical and blinatumomab clinical data, the model was created and validated. The initial step-fractionated dose was projected to minimize systemic T-cell activation and cytokine release without impairing tumour response.
Simulations described the mechanisms underlying the observed cell and cytokine (IL6) dynamics. The Phase I clinical study for mosunetuzumab was changed to a step-fractionated treatment schedule as a result of these findings, allowing for the safer administration of greater dosages.
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Answer:
Plant transport systems move energy from leaves and raw materials from roots to all their parts. The xylem (tissue) moves water and minerals obtained from the soil to all other parts of the plants.
Explanation:
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I believe this leads to allostatic load. Allostatic load is the cumulative biological burden exacted on the body through daily adaptation to physical and emotional stress. it is considered to be a risk factor for diseases such as obesity, coronary vascular disease, diabetes, .cognitive impairment, depression and inflammatory and autoimmune disorders.
The possible phenotypes are AB, BB, AO, and BO
