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insens350 [35]
3 years ago
14

Complete the sentence:

Biology
1 answer:
fomenos3 years ago
6 0
Re: A car driver automatically brakes if a child dashes across the road.
<span>This is called a .............................................. reaction.
answer: reflex</span>
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A number of mutations have been described in the G protein Ras that have profound effects on its activity. For example, some mut
gladu [14]

Answer:

a mutation that blocks the GTPase activity of Ras

Explanation:

A G protein in inactive state is GDP bound but as soon as a guanine exchange factor (GEF) exchanges it with GTP it gets activated which means that in GTP bound state it is active. G - protein has endogenous GTPase activity. Upon interaction of GAP, the GTPase activity of this protein is exhibited. When GAP is present, hydrolysis of GTP into GDP occurs which leads to inactivation of G protein. A mutation which will block GTPase activity of Ras will therefore result in constitutive active signaling even in the absence of ligand binding to it's receptor. In such scenario, GTP will not be hydrolyzed into GDP so signaling will be up-regulated.

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