Numerous antiepileptic medications, such phenytoin, have been designed to block voltage-gated sodium channels (VGSC) in neuronal membrane. In addition, multiple toxins and pharmacological modulators work by attaching to various biophysical states of the VGSC to cause their effects. Depending on how modulatory agents act, some VGSC states are stabilized or destabilized, altering the channel's biophysical properties. The first anticonvulsant to successfully treat epileptic disorders without causing undesirable side effects such as brain drowsiness was phenytoin.
Phenytoin has been indicated to block high-frequency neuronal activity potentials from the inner vestibule of the pore, as demonstrated by electrophysiological research and site-directed mutation.
Frequency and voltage both affect phenytoin binding.
There are theories that phenytoin interferes with the late sodium current that sustains depolarizations in epilepsy by blocking non-inactivated channels.
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Answer:
1-Mouth:the mechanical digestion takes place in mouth with the help of teeth. chewing is the machanical digestion of food in mouth.
2-Stomach: by the churning process. churning is the mixing of food in stomach by the movements of smooth muscles in stomach wall.
Explanation:
These defenses are described as nonspecific because they do not target any specific pathogen; rather, they defend against a wide range of potential pathogens.
<h3>Is innate immunity nonspecific resistance?</h3>
The innate immune system provides this kind of nonspecific protection through a number of defense mechanisms, which include physical barriers such as the skin, chemical barriers such as antimicrobial proteins that harm or destroy invaders, and cells that attack foreign cells and body cells harbouring infectious agents.
Thus, they do not target any specific pathogen; rather, they defend against a wide range of potential pathogens.
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C) its protein synthesis. any thing that has to do with proteins are ribosome. not lipids.
Prophase: spindle fibers are developed during this phase.
