A liver biopsy of a four-year-old boy indicated that the fructose-1,6-bisphosphatase enzyme activity was 20% of normal. the pati
ent's blood glucose levels were normal at the beginning of a fast but then decreased suddenly. pyruvate and alanine concentrations were also elevated. explain the reason for this symptom.
Fructose-1,6-bisphosphatase is a key enzyme in glycolysis and gluconeogenesis; but in this case, the function of this enzyme in gluconeogenesis is more significant. Gluconeogenesis is reversal of glycolysis by bypassing irreversible reactions of glycolysis and making use of reversible reactions of glycolysis. In turn, compounds such as pyruvate, alanine, and glycerol will eventually be converted back to glucose. In the liver, this glucose can be released in the bloodstream in response to hypoglycemic states (i.e. fasting states).
In the deficiency of fructose-1,6-bisphosphatase, gluconeogenesis will be impaired. Therefore there will be an abnormal decrease in blood glucose levels during fasting. Substrates for gluconeogenesis (i.e. pyruvate and alanine) will then accumulate in the body causing its levels to increase.
It is an example of uneasiness. It is because being anxious is a way of having to be worried to a specific thing or problem in which when a particular person is worried, he or she is likely feeling anxious as he or she seeks for something that will relieve his or her worries.
Insulin suppresses hepatic glucose output and adipose tissue lipolysis, lowering blood glucose and fatty acid levels. It also increases hepatic lipid synthesis for subsequent storage in adipose tissue and stimulates glucose uptake into fat and muscle.
