What trade routes connected missouri to mexico in 1821?
Explanation:
<u>The Santa Fe Trail was opened in 1821</u>, <u><em>was a famous route of transport of the XIX century that ran through the center of North America</em></u>, <u>connecting the cities of Independence (now Missouri) and Santa Fe (today New Mexico).
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<u><em>The answer is</em></u>: <u>The Santa Fe Trail was opened in 1821.
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