I think the most critical consequence of the advancement of the amniotic egg it the tetrapods were no longer attached to the water for reproduction.The amniotic egg permits reptiles, flying creatures, and warm-blooded creatures to lay eggs ashore without drying out. The liquid filled depression containing the incipient organism is isolated from the outer condition by an amniotic sac that is impermeable to water.
Science subject demonstrate observation
Social welfare department observation
Most color pigmentation goes towards hair and not much is left for skin.
I would say 1 and 4 are the best answers. GMO crops are clones (genetically identical) so it reduces the genetic diversity making crops susceptible to new diseases.