<span>C. Gametes are the sex cells, and each (sperm and ovum) contain half of the parent's genetic material. These cells will fuse to produce a zygote, which will usually contain the full number of genes required by an organism to live. If there is a chromosomal abnormality, such as a gamete with an extra chromosome, the offspring can either die in development or sometimes be born with physiological and/or developmental difficulties. An example of this phenomenon is trisomy 21, also known as Down Syndrome, in which the 21st chromosome bears 3 copies instead of the regular 2.</span>
There are so many examples for that in different areas, like biology experiment carried out in our lab recently.
Here's one link:https://www.creative-biogene.com/support/Knockout-Cell-Lines-in-Antibody-Screening-and-Validation.html
They might be deep inside
