Effects that are dependent on the size of the population and regulate the growth of populations are called density-dependent effects.
The Black Death is estimated to have killed 30–60% of Europe's total population. In total, the plague may have reduced the world population from an estimated 450 million down to 350–375 million in the 14th century.
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Therefore, economic gain and religion were the two factors that most affected the dynamics of European and indigenous American relationships. The Spanish: ... Indigenous populations declined over the seventeenth century as epidemics brought by the Spanish killed large numbers of natives.
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