<span>A drug used to treat CML, imatinib, binds to the active site of Abl kinase. Why does this drug work to treat this type of cancer?
</span><span>B) By binding to the active site, the drug prevents the ability of Abl kinase to bind to its substrate.
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Imatinib works against CML by binding close to the ATP binding site of bcr-abl. The binding results to the<span> locking in of the bcr-abl to a closed or self-inhibited conformation and inhibiting the enzyme activity of the protein </span><span>semi-competitively.</span>
<span>Active transport works to conserve homeostasis. When cells are doing something they typically receive a signal causing channels to open, which in turn lets in a flood of molecules down their chemical gradients. Hope this answers the question.</span>
<span>What is the approximate age of our solar system?
</span>b. 4.6 billion years
