Due to various trehalose's importance in pathogenic organisms, there has lately been a surge of interest in trehalose metabolism for therapeutic applications.

TPP (trehalose-6-phosphate phosphatase) is an important enzyme in the most important biosynthetic pathway (OtsAB).
The enzyme properties of recombinant TPPs from five key nematode and bacterial pathogens, including three new members of this protein family, are compared here.
The kinetics of trehalose-6-phosphate hydrolysis demonstrate that all five enzymes exhibit burst-like kinetic behaviour, defined by a drop in enzymatic rate beyond the pre-steady state.
Multiple global conformational changes in members of this enzyme family during substrate processing can explain the observed super-stoichiometric burst amplitudes.

Hence, the correct answer is option A

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# SPJ4

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