It would be "germs and disease" that had the greatest impact when the Old and New Worlds met, since the Natives in the New World were not immune to the germs that the Europeans were carrying--leading thousands of Natives to be killed.
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Increasing demands on the American
colonies by the King of England, Writing the Declaration of Independence,
Developing the US Constitution
Laissez-faire or free enterprise system is the principle wherein the government has little or minimal interference in the nation's economy.
This principle allowed more people to open, specialize, and industrialize their business efforts. This practice boosted the economy making more profit not only for the business people but for the nation as a whole.
It also benefited consumers because they were able to have more choices in terms of basic and luxury products.