They rose due to nationalism. Germans wanted revenge for WW1 where they thought they were punished too harshly, while Japan deemed that it was a great nation and that it should enter the continent through China. Germans fell because they became too spread out and couldn't fight the war an all fronts, while the Japanese lost it because they enraged the US who nuked them.
The answers is 2. Acetylcholine
I believe it is the generic but I may be wrong about that.
Hope that helps and feel free to ask me more questions :)
Brainliest??