Answer: It made making a new constitution easier.
Explanation: When James Madison and the other 56 delegates to the Constitutional Convention met in Philadelphia in May 1787, they intended to amend the Articles of Confederation. They ended up creating a new constitution, and Madison, representing Virginia, became the chief recorder of information (he took a lot of notes).
The main impact on the Americas from the Colombian Exchange was how many Indigenous people were killed. The exchange transferred European diseases, such as syphilis, smallpox, mumps, chicken pox, and the flu, to the Americas (which native people had not experienced). Many died as a result of a lack resistance or cures to these new diseases.
Investigating the reasons Slavery was canceled. In 1807, British Parliament abrogated the purchasing and offering of slaves. Shockingly, until 1833-when all parts of subjugation were abrogated you were still permitted to claim a slave. This sickened people in general thus they made a stop to bondage.