Common Sense by Thomas Paine was highly instrumental in convincing the colonists that they should separate from Great Britain, since it called into question the idea that such a vast and prosperous land should need the support of a small island nation (Britain).
One effect that the end of the British war with France had on the War of 1812 was that "<span>It freed large numbers of British troops to fight in North America," since Britain was only fighting one major war at this time.</span>
The themes that played a major role in changing the world between 1450 and 1750 was that plants were being spread together with animals and diseases between the Americas and the rest of the world; mainly Europe. Especially famous are cases where European contact wiped out whole villages and tribes of native American people because they were unable to cope with the bacteria and viruses.