It is called THERAPEUTIC INDEX. Therapeutic index is the comparison of the amount of a particular drug that causes the desired therapeutic effects and the amount that causes toxicity. The index can be low or high. A drug with a low therapeutic index will require only a small increase in dose to produce toxic effects in users.
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This condition is known as a super oxide in which mutated enzyme extremely functional because it helps in production of cells .
when unstable molecules that contains oxygen and that easily react with other molecules in the cells. a build up of reactive oxygen species and cells causes damage of DNA ,RNA & protein ,which cause cell death.
super oxide refers various toxic oxygen containing free radicals such as monovalant anion O2 (negative) or that compound containing potassium super oxide KO2. reactive oxygen can cause damage to the basic building block of the cell. DNA damage can occur in the form of double stranded breaks as a result of reactive oxygen induced conversion of guanine to 8-oxo guanine.
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