C. Perspective. Leonardo's background gives depth and a massive, heavenly, grand, operatic feel to the painting. This differs from other Da Vinci works which are more intimate and lack large perspective scale.
Space in art refers to the emptiness or area around, (or between, above, below, within, etc.) objects. Positive space is the shapes or forms of interest, (the actual art part) and negative space is the empty space between the shapes or forms.