Vitamin B12 deficiency causes anemia that affects neurological system and higher level of folate helps in preventing anemia by preventing deterioration of brain cells.
In B12 deficiency, folate cycle get disrupted that affects regeneration of methylene-tetrahydrofolate which is required for the synthesis of thymidine for DNA replication. Folate is trapped as methylfolate and causes folate deficiency which demands for the supply of folic acid.Folic acid is recommended to a B12-deficient patient, as it allows the reduction of folic acid to dihydrofolate and further to tetrahydrofolate which removes the blockage of folate. this helps in the masking of brain cells to get deteriorate due to deficiency of B12.
