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forsale [732]
3 years ago
9

PK-M2 has also been found in many tumor cells, but is in an inactive state. Explain why this seemingly counterintuitive discover

y is actually a benefit for tumor cells.
Biology
1 answer:
katen-ka-za [31]3 years ago
8 0
Pyruvate kinase muscle isozyme M2 (PKM2) is a limiting glycolytic enzyme that catalyzes the final step in glycolysis, which is key in tumor metabolism and growth. The present review discusses the expression and regulation of PKM2, and reports the dominant role that PKM2 plays in glycolysis to achieve the nutrient demands of cancer cell proliferation. In addition, the present study discusses the non-metabolic function of PKM2, and its role as a coactivator and protein kinase, which contributes to tumorigenesis. Furthermore, conflicting studies concerning the role of PKM2 as a therapeutic target are reviewed. The improved understanding of PKM2 may provide a noval approach for cancer treatment.

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ruslelena [56]
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8 0
3 years ago
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Kay [80]

Answer:

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Genetics is a discipline that studies the transmission of heritable traits from parents to offspring. Population genetics is a discipline that analyzes genetic and allele frequencies in natural populations, as well as their changes in evolutionary processes. Finally, molecular genetics is a research field that studies the structure of the DNA molecule, its replication and the development of genetic engineering technologies associated with the manipulation of genetic information.

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Stolb23 [73]
<h2>PLEASE MARK IT BRAINLIEST </h2>

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3 years ago
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cluponka [151]
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