Many different ways, primarily through bone and muscle loss. The lack of pressure on bones causes the body to reabsorb calcium from them, weakening them and potentially causing kidney stones.
To convert to scientific notation, start by moving the decimal place in the number until you have a coefficient between 1 and 10; here it is 3.45. The number of places to the left that you had to move the decimal point is the exponent. Here, we had to move the decimal 4 places to the right, so the exponent is -4.