Answer:
Delivered small RNAs can inhibit protein A production through the RNA interference (RNAi) mechanism, and thus impairs angiogenesis
Explanation:
The pregnancy-associated plasma protein-A is a protease enzyme involved in the formation of new blood vessels by increasing insulin-like growth factor I (IGF-I) bioavailability. Moreover, small RNAs (<200 nucleotides in length, generally 18 to 30 nucleotides) are non-coding RNA molecules that function in RNA silencing through the RNA interference (RNAi) pathway. Small RNAs are widely used in molecular biology laboratories because they can be delivered into specific cells in order to silence target mRNAs such as, in this case, the mRNA encoding protein A, by complementary base pairing and thereby inducing translational repression. In consequence, mRNAs complementary to delivered small RNAs are silenced through RNAi pathways, i.e., by cleavage of the target mRNA and/or mRNA destabilization.
It is also known as a rescue agent
Answer:
destructive force breaks down features of earth's surface/ constructive forces build up features of earth's surface
How does a new hypothesis replace an older explanation of something in the natural world? To understand this let us look at one of the classical example of geocentric theory and heliocentric theory. The geocentric theory states the Earth is at the centre of the solar system and the Sun, Moon, and all the other planets revolve around it. This ancient theory failed to explain the phenomenon like the phases of Moon, solar eclipse and lunar eclipse. The modern heliocentric theory which states that the Sun is at the centre of solar system, and all the planets including the Earth revolve around it. This theory was able to explain all the phenomenons unlike the geocentric theory. Hence the heliocentric theory replaced the geocentric theory.
