The dose should be adjusted to achieve and maintain therapeutic drug levels
Noah's principle is a concept that comes from the Biblical story found in the old testament where God gave Noah instructions to build an ark to save him and his family .
The concept here is that God did not tell Noah when it was going to rain. The people of the day most probably mocked and derided Noah as a time waster or a fool. That is, until the flood came. The " fool" had been wiser all along.
An Application is this. Google gives everyone who does online business "suggestions" and "guidelines" but not everyone chooses to listen. Google rarely, if ever, tells us when they will put the guidelines into action.
Panda, a Google ranking system, took 6 years while Google was telling online users to follow certain guidelines. Many ignored, until Panda was put into action, and those who had not heeded suffered with only themselves to blame.
Moral: Heed and prepare even if the outcome tarries.
Sternocleidomastoid muscles.
Explanation:
The neck movements like flexion, rotation, extension, lateral rotation and flexion are carried out by neck muscles which include the sternocleidomastoid muscle,
The sternocleidomastoid muscle is a pair of muscle located superficially in the anterior neck.
The sternocleidomastoid muscles connects skull with the clavicle and hence is involved the head and neck motions.
The `bilateral contraction movements of sternocleidomastoid muscles aids in flexion of the neck and brings the chin down towards the breastbone.
Platysma is a facial muscle and involved in facial expressions and mandibular movements
Semispinalis muscle is in the posterior neck and maintains posture and head movements.
Trapezius muscles lies at the back of the head.
I would personally say stem cells as your answer.