Answer:
The answer is reciprocal chromosomal translocation
Explanation:
The Philadelphia chromosome (Ph) is the truncated chromosome 22 generated by the reciprocal translocation t(9;22)(q34;q11) and was first identified in 1960 in a patient with CML [3]. Translocation of the proto-oncogene tyrosine-protein kinase (ABL1) gene located on chromosome 9 to the breakpoint cluster region (BCR) gene located on chromosome 22 results in a BCR-ABL1 fusion gene on the Ph [4, 5]. Three BCR-ABL1 fusion gene hybrids encode BCR-ABL1 protein isoforms p210, p190, and p230, which have persistently enhanced tyrosine kinase (TK) activity. These aberrantly activated kinases disturb downstream signaling pathways, causing enhanced proliferation, differentiation arrest, and resistance to cell death [6, 7]. Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL1 protein are the most successful targeted therapy for Ph-positive leukemia.
Answer:
1 living organisms are composed of one or more cells.
2 The cell is the basic unit of structure and organization in organisms.
3 Cells arise from pre-existing cells.
Answer:
The simplest virions consist of two basic components: nucleic acid (single- or double-stranded RNA or DNA) and a protein coat, the capsid, which functions as a shell to protect the viral genome from nucleases and which during infection attaches the virion to specific receptors exposed on the prospective host cell.
Answer:
C, a long absolute refractory period.
Explanation:
Tetanus is not possible in cardiac muscle tissue because cardiac cells have longer action potentials and a very long refractory period compared to other cells. This helps prevent the heart from cramping and seizing up.
The mother may feel guilty about her child's condition because she may think that the child had that disease genetically from one or both of his or her parents. The mother may exhibit signs of self-blaming because she feels like it is her fault that her child is suffering from the disease. The healthcare practitioner should approach the mother in a biopsychosocial approach wherein the mother is allowed to vent out (catharsis), then the healthcare practitioner should make things clearer (educate), and then have the appropriate action given.
