The proprioceptors are the sensors in the limbs, which give information regarding the muscle length, joint angle, and muscle tension that is combined to provide knowledge regarding the alignment of the limb in space. The muscle spindle is one of the kinds of proprioceptor, which gives information regarding the changes in the length of the muscle.
On the other hand, a nociceptor refers to a sensory neuron, which reacts towards the potentially damaging or destructing stimuli by conducting probable danger signals towards the brain and the spinal cord.
Proprioceptors are to reflex actions as nociceptors are to pain perception.
Intelligence, it does not have any direct correlation with evolution and is not supported by factual evidence.
The lysosomes are responsible for that
HOXC8 gene encodes a protein that has a role in the development of the cartilage. This gene is a member of the HOX group gene that enables the differentiation of the body segments. These genes encode for transcription factors that activate the expression of other specific genes guiding the differentiation of body segments into specific structures.