Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Answer:
the correct answer is D
Explanation:
skin excretes sweat; lungs excrete carbon dioxide; kidneys excretes urine so these organs excrete metabolic waste because if you have learnt about the excretory system, you will come to know the process of excretion and how we humans excrete metabolic and toxic waste from the body.
<span>An ecosystem consists of a population of organisms and its
physical environment, and a population is made up of many different
communities of organisms. Every one of the creatures of similar species
living together that live in a particular biological system are known
as a populace The people in the populace contend with one another for
sustenance, settling space, and mates.</span>
Answer: When you study environmental science, you commit to learning of accomplish important tasks for our Earth and our human population.
Explanation: Hope this helps! :)