Answer:
1. P120 is degraded in the 26S proteasome
2. The 26S proteasome has a major role in protein degradation and is critical for protein homeostasis
3. Cell cycle and DNA replication are cellular processes regulated by the Ras and NFkB pathways
Explanation:
The proliferation-associated nucleolar protein (p120) is a protein known to be expressed during the interphase of the cell cycle, specifically in G1 and early S phase, where any problem with DNA replication trigger a checkpoint, i.e., a molecular cascade of signaling events that suspend DNA replication until the problem is resolved. In mammalian cells, the 26S proteasome is responsible for catalyzing protein degradation of about 80% (or even more) of their proteins. The 26S proteasome acts to degrade rapidly misfolded and regulatory proteins involved in the cell cycle, thereby having a major role in protein homeostasis and in the control of cellular processes. It is for that reason that inhibitors that block 26S proteasome function have shown to be useful as therapeutic agents in diseases associated with the failure of protein degradation mechanisms (e.g., multiple myeloma). The NF-κB are highly conserved transcription factors capable of regulating different cellular processes including, among others, cellular growth, inflammatory responses and apoptosis. Moreover, the MAPK/ERK pathway is able to transduce different signals received on the cell surface to the nucleus. The MAPK/ERK pathway is activated when a singling molecule binds to a cell receptor which triggers a signaling cascade that ends when a transcription factor induces the expression of target genes, ultimately producing a response in the cell (for example, the progression through the cell cycle).
If this answers your question:
Disaccharides are formed when 2 sugar molecules combine. An example of this is Maltose
Answer: A warm current is just the reverse. A warm current is moving away from the Equator toward the poles. The water in a warm current is warmer than the surrounding water.
Explanation: The surface water temperature varies considerably between the Equator and the poles. As the ocean water is distributed across the Earth's surface by drifts and currents (see the infrared satellite photo of the warm Gulf Stream moving north along the east coast of Florida), warm water from the lower latitudes is moved into the higher latitudes and cold water is moved Equatorward. If you will remember, we noted in the section on Latitude that this redistribution of heat by ocean water is one of the major ways excess energy is moved poleward (and cold water is moved Equatorward).
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Answer:
Antibiotics cannot kill viruses because bacteria and viruses have different methods to survive and replicate. Viruses replicate via inserting their DNA into a host cell.
Explanation:
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